Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 5th International Conference on Gynecology | Obstetrics | Reproductive Health & Medicine | PCOS Zurich, Switzerland.

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Scientific Program Day 1
Scientific Program Day 2

Day :

  • Occupational Health and Risk Management | Occupational Public Health | Occupational Health and Industrial Hygiene | Occupational Health and Mental Health | Occupational Health Psychology and Work Environment
Location: Sylt 1-2

Session Introduction

Marian Gugushvili

David Tvildiani Medical University, Gerogia

Title: Risk factors of functional hyperandrogenesis: Case control study
Biography:

Mariam Gugushvili has experience of working since 5 year up to present working in Medical corporation Evex as Medical doctor in obstetrics and gynaecology department. 2015 up to present-working in David Tvildian medical university as assistant in Obstetrics and Gynaecologic department. 2015 up to present visiting Lecturer in David Tvildiani Medical University –Anatomy and pathology subjects. In 2018 she become a member of The European MD/PhD Association, in 2018 she Become a board member and Georgian representative in EUROPAG. she was working on this subject “hirsutism in Georgian population “with professor Besarion Tkeshelashvili for 2016 year. Research gives us more information how to make management of patients who has functional hirsutism, nowadays she is working on her PhD program

Abstract:

Objective: The purpose of this study was to establish risk-factors of functional hyperandrogenism (FH) in ethnically Georgian adolescents with polycystic ovary syndrome (PCOS). Material and Methods: 286 female adolescents (14-20 years) randomly selected for case-control study. Anthropometric measurements including waist, height, weight and body mass index were evaluated. Transabdominal ovary ultrasonography was performed for all subjects in days 7-14 of menstrual cycle. Blood fasting samples were collected
to measure serum levels of free testosterone, total testosterone, DHEA-S, androstenedione, 17-hydroxyprogesterone, FSH, LH, SHBG, prolactine, cortisol, TSH. PCOS was defined by the diagnostic criteria of Androgen Excess and PCOS Society. Following risk factors were studied: sleep disorder (late bedtime habits or night deprivation or short
sleeping time); rare meal intake habits (<3) and/or breakfast skipping; sugar-rich and/or protein-lack diet.
 
Case group: n=71 adolescents with PCOS, corresponding control group - n=215. For the evaluation of quality of life standard questionnaire EQ-5D-5L created by the EuroQol Group has been used.
 
Results: From sleep disorders sleep deprivation in PCOS adolescents was revealed more frequently than in controls (44,79% vs. 39.01%; OR=1.2679, 95%CI – 1.0632 to 1.5120, p=0.0082). Same association was in case of rare eating habits or skipping breakfast – odds ratio for this factor is higher in case group vs. controls (43,04% vs. 38.49%; OR=1.2079, 95%CI – 1.0122 to 1.4415, p=0.0362).
Our results revealed a significant difference for sugar-rich/protein-lack diet between PCOS adolescents vs. controls (57,25% vs. 50.47%; OR=1.3139, 95%CI – 1.0123 to 1.5661, p=0.0023). The value of quality of life in investigated PCOS (76.66 ± 12.73) (77.75 ± 11.79) group was significantly
lower than in control group (87.02 ± 12.03).
 
Conclusion: Stress conditions such as sleep disorders, reduced frequency rate of meal intake and/or breakfast skipping,sugar-rich and/or protein-lack diet is  accompanied by the  development of an FH and PCOS.

Shayesteh Jahanfar

Central Michigan University, USA

Title: Age of menarche heritability and birth weight
Biography:

Shayesteh Jahanfar is a Reproductive Epidemiologist with grounding in public health and biostatistics. Her research focuses on reproductive health, women
and children health and genetic versus environment studies. She has worked with a number of twin studies in Australia, Iran, Malaysia and Canada. She has
conducted several epidemiological studies and produced over 15 systematic reviews in the areas of HIV/AIDS, domestic violence, family planning, ultrasound screening and breast-feeding. She is an International Cochrane Trainer who has conducted over 20 Cochrane workshops/webinar series on standard author training and trained over 400 clinicians and scientists. She has over 60 peer-reviewed publications including Nature Perinatology, Fertility & Sterility, Cochrane Library and Journal of Fetal and Maternal Medicine. She is currently working towards conducting several twin studies, a randomized controlled trial and a longitudinal study all related to reproductive health and reproductive behavior at national and international levels. She is interested to work with interested students and researchers for potential collaboration.

Abstract:

Background: Genetic and environmental factors both influence on age of menarche. However, it is not clear how much of intra-uterine environmental factors particularly sex discordance and birth weight affects the onset of
menarche.
 
Method: To investigate the genetic and environmental contributions to the association between birth weights with onset of menarche, we studied twins registered at State Washington Twin Registry. A group of female-female
monozygotic (n=994, 497 pairs), female-female dizygotic (n=296, 148 pairs) and females from opposite sex twin sets (n=168) replied to a reproductive health questionnaire. The primary goal of this study was to use a modern
maximum likelihood quantitative genetic method to estimate the heritability (h(2)) of age at menarche. The second goal was to study the role of sex discordance and birth weight on onset of menarche.
 
Result: After adjusting for birthweight, the monozygotic correlation for age of menarche (0.59) was about 4.21 times the dizygotic correlation (0.14). Birth weight was positively associated with age of menarche (r=0.07, p<0.01) but
not sex discordant.
 
Conclusion: Age of menarche is genetically determined. From the potential intra-uterine environmental factors, birth weight seems to be related to age of menarche but not sex discordance.

Masahiro Onuma

President of Trisguide ltd, Japan

Title: Electronic water can reduce oxidative stress in PCOS patients for 3 weeks drinking
Biography:

Masahiro Onuma has expertise in oxidative disease prevention to use non-medical product based on GSK’s experience of Allopurinol which is the strongest antioxidant efficacy in this world. He creates new indication of Allopurinol for stomatitis induced by cancer treatment which was approved by the Japanese Cancer treatment committee to propose new mechanism of Allopurinol for anti-oxidant. And now, there are so many new research papers of Allopurinol in the world.

Abstract:

Oxidative stress means a state there is imbalance between the oxidizing action and the reducing action due to reactive oxygen species (ROS) in a living body, resulting in the oxidizing action becoming dominant. Oxidative stress arises as the balance between production and removal is disrupted through excessive production of ROS and impairment of the antioxidant system. Oxidative stress has been reported to be involved in the onset and progress of various diseases. Characteristics of Type 2 diabetes are insulin secretion failure and insulin resistance, but it seems that oxidative stress is greatly involved in insulin secretion failure. Oxidative stress (OS) has received extensive attention in the last two decades, because of the discovery that abnormal oxidation status was related to patients with chronic diseases, such as diabetes, cardiovascular, polycystic ovary syndrome (PCOS), cancer, and neurological diseases. OS is considered as a potential inducing factor in the pathogenesis of PCOS, which is one of the most common complex endocrine disorders and a leading cause of female infertility, affecting 4%–12% of women in the world, as OS has close interactions with PCOS characteristics, just as insulin resistance (IR), hyperandrogenemia, and chronic inflammation. Electronic water, which was developed to generate electron in water, was consumed for three weeks, after meals, between meals and before sleeping 6 times a day, and according to the test subjects' possible time periods. The amount of drinking water was 750-1000 mL, and BAP and d-ROMs checks for all cases were carried out at 4:30 pm. The results of cancer patients and diabetes patients were seen as attached. As a result, the d-ROMs value in the degree of oxidative stress has reduced, and the BAP value, which is an indicator of plasma antioxidant capacity, has improved significantly.

Shayesteh Jahanfar

Central Michigan University, USA

Title: Age of menarche, heritability and birth weight
Biography:

Shayesteh Jahanfar is a Reproductive Epidemiologist with grounding in public health and biostatistics. Her research focuses on reproductive health, women
and children health and genetic versus environment studies. She has worked with a number of twin studies in Australia, Iran, Malaysia and Canada. She has
conducted several epidemiological studies and produced over 15 systematic reviews in the areas of HIV/AIDS, domestic violence, family planning, ultrasound screening and breast-feeding. She is an International Cochrane Trainer who has conducted over 20 Cochrane workshops/webinar series on standard author training and trained over 400 clinicians and scientists. She has over 60 peer-reviewed publications including Nature Perinatology, Fertility & Sterility, Cochrane Library and Journal of Fetal and Maternal Medicine. She is currently working towards conducting several twin studies, a randomized controlled trial and a longitudinal study all related to reproductive health and reproductive behavior at national and international levels. She is interested to work with interested students and researchers for potential collaboration.

Abstract:

Background: Genetic and environmental factors both influence on age of menarche. However, it is not clear how much of intra-uterine environmental factors particularly sex discordance and birth weight affects the onset of
menarche.
 
Method: To investigate the genetic and environmental contributions to the association between birth weights with onset of menarche, we studied twins registered at State Washington Twin Registry. A group of female-female
monozygotic (n=994, 497 pairs), female-female dizygotic (n=296, 148 pairs) and females from opposite sex twin sets (n=168) replied to a reproductive health questionnaire. The primary goal of this study was to use a modern
maximum likelihood quantitative genetic method to estimate the heritability (h(2)) of age at menarche. The second goal was to study the role of sex discordance and birth weight on onset of menarche.
 
Result: After adjusting for birthweight, the monozygotic correlation for age of menarche (0.59) was about 4.21 times
the dizygotic correlation (0.14). Birth weight was positively associated with age of menarche (r=0.07, p<0.01) but
not sex discordant.
 
Conclusion: Age of menarche is genetically determined. From the potential intra-uterine environmental factors, birth weight seems to be related to age of menarche but not sex discordance

Maria do Carmo Baracho de Alencar

Federal University of Sao Paulo, Brazil

Title: The suffering of nutrition attendants of a public hospital affected by RSI/WRMSD
Biography:

Maria do Carmo Baracho de Alencar has completed her PhD at Federal University of Santa Catarina, Brazil. She is the Associated Professor and Member of  Health, Education and Society Department, Institute of Health and Society of the Federal University of Sao Paulo (UNIFESP), Brazil.

Abstract:

The aim of this study was to understand the relationship between aspects of the work organization and the health of nutrition workers affected by RSI/WRMSD. Throughout the process, absenteeism statistics related to RSI/WRMSD were obtained from a Public Hospital in Porto Alegre/Brazil, from 06/01/2015 to 06/30/2016, and a section of such hospital was selected for further study. A selection of the food distribution section and its nutrition attendants for the research occurred because of having a high absenteeism level related to the sickness of RSI/WRMSD. A structured questionnaire with sociodemographic and professional data and the Self-Reporting Questionnaire (SRQ-20) were used to investigate the prevalence of common mental disorders (CMD), and collective interviews were conducted with nutrition attendants affected by RSI/WRMSD, recorded and transcribed for content analyses, and using the theoretical reference of the work psychodynamics. Participated in the questionnaires and SRQ-20 application 113 nutrition attendants, most of the female gender (97.3%) and 74.3% aged above 40 years and 48.6% with a common mental disorder (CMD). The low back pain was the most common body region affected (62.8%), among others. Results include the collective interviews a total of 19 nutrition attendants participated in eight meetings. Qualitative results obtained pointed to ways of organizing and managing work which included excessive pressure, moral harassment and lack of recognition, generating suffering and influencing the processes of illness

Rebecca Purc-Stephenson

University of Alberta, Canada

Title: To tell or not to tell: The role of employer practices and organizational culture in employees’ decision to disclose a disability
Biography:

Rebecca Purc-Stephenson is an Associate Professor of Psychology in the Augustana Faculty at the University of Alberta. She has completed her Graduation at the University of Windsor from the Applied Social Psychology program. She maintains an active research program, and her research interests include health, illness, work and access to services for the socially disadvantaged. Her most recently funded research program examines how individuals with a physically disability find and maintain stable employment. She has published over 20 papers in scholarly journals, presented over 30 papers at national or international conferences, and serves as an Editorial Board Member for one academic journal.

Abstract:

Disclosing a disability to an employer is usually necessary to receive workplace accommodations. However, many employees consider disclosure a risky action that could result in lowered supervisor expectations, fewer
promotional opportunities, segregation from co-workers, and increased likelihood of termination. Much of the existing research exploring the reasons for disclosure focus on employee characteristics and/or their relationship
with their supervisor. Recent research shows that several employer practices, ranging from having accessible physical environments to including a message of disability inclusiveness on the organization’s website, may be important
cues that an organization is “disability friendly” and therefore encourage disability disclosure. The purpose of this study was to determine what employer practices or workplace characteristics contribute to a “disability-friendly” organizational culture, and how this relates to employee disclosure decisions. Using survey methodology, data were collected from a convenience sample of 350 employees to develop a new 25 item assessment tool, called the Inclusive Workplace Survey (IWS), that measures the perceived disability inclusiveness of an organization. A second sample of 128 employees with physical disabilities was collected to test the new survey and hierarchical regression was used to determine what factors predict disability disclosure. In addition to employee health status, the strongest predictors of disability disclosure were having control and flexibility at work, feeling supported by co-workers and supervisor, and working in a visibly diverse workplace. This presentation will describe the new IWS tool and summarize the relationship between employer practices, organizational culture, and disability-disclosure decisions. Understanding how employees make decisions about disclosure in the workplace may inform organizational policies, practices and programs to improve the experiences of individuals living with a disability.

Emmanouella Chatzidaki

Institute of Molecular Biotechnology, Vienna, Austria

Title: Ovulation suppression prevents the increase in egg aneuploidy with maternal age
Biography:

Dr. Emmanouella Chatzidaki has completed his PhD at the age of 26 years from the Univeristy of Cambridge, UK and postdoctoral studies from Karolinska Isntitute, Sweden 

Abstract:

The frequency of egg aneuploidy and trisomic pregnancies increases with maternal age. Since multiple causes contribute to egg aneuploidy, it is likely challenging to prevent the “maternal age effect” using a single approach. To test our hypothesis that ovulations contribute to oocyte ageing and chromosome missegregation, we used genetics, hormonal contraception and successive pregnancies to reduce ovulations. We observed that ovulation reduction is sufficient to prevent egg aneuploidy and age associated errors during meiosis I division of the oocyte, in aged mice. By interrupting ovulations with successive pregnancies, we discovered that eggs from aged mated females display lower aneuploidy and reduced precociously separated sister centromeres compared to those from aged virgin females. When putting mice on hormonal contraception we find a near 2 fold reduction in aneuploidy incidence. To reduce ovulations further, we generated Gpr54 knockout mice, which remain in a pre-pubescent state. Remarkably, aneuploidy is reduced 3-fold in eggs from Gpr54-/- versus Gpr54+/+ aged females. These data suggest protection is due to reduced ovulations. We further observed that ovulations contribute to loss of Rec8-cohesin, which is essential for sister chromatid cohesion in meiosis. Single-nucleus Hi-C revealed a deterioration of 3D chromatin organization that depends on ovulation frequency and Rec8, which restricts loops extrusion. We conclude that ovulation suppression leads to retention of Rec8, which maintains chromatin structure and promotes chromosome segregation and production of euploid eggs. Our work implies that hormonal contraception can reduce the risk of Down’s syndrome pregnancies at advanced maternal age.

Marlee Madora

Montefiore Medical Center, USA

Title: Peripartum ethical considerations in a pregnant psychotic patient
Biography:

Marlee Madora completed her medical degree at Sidney Kimmel Medical College of Thomas Jefferson University. She is a second year resident in psychiatry at Montefiore Medical Center and is particularly interested in womens mental health. Rachel Noone completed her medical degree at Penn State University and is a graduate of Montefiore Medical Center’s Psychiatry Residency. She specializes in the treatment of patients with serious mental illness and works at the Inpatient Psychiatry Unit at Montefiore Wakefield Campus.

 

Abstract:

CM is a 41yo G2P1 domiciled in supportive housing with supraventricular tachycardia, chlamydia and chronic severe schizoaffective disorder who presented to the hospital during her second trimester with worsening psychosis.  She expressed the delusion that the father of her child was a celebrity who was not giving her money for food. She was involuntarily hospitalized for decompensated psychosis and refused antipsychotics due to paranoia.  She was taken to court for treatment over objection and was court ordered for treatment with olanzapine. Despite receiving a maximum daily dose of olanzapine, the patient continued to be paranoid, delusional, isolative and unable to care for herself throughout her entire pregnancy.  She had a C-section at term, and was subsequently monitored on the cardiology unit for tachycardia.  After medical stabilization, she was transferred back to psychiatry for management of persistent psychosis. Child Protective Services (CPS) was called and the baby was remanded due to the patient’s severe psychosis with inability to care for herself or the child. The patient then requested to visit her child and breastfeed while her baby was in the neonatal intensive care unit for respiratory issues.  Using a relational ethics framework, the multidisciplinary team decided that the risk of disrupting the mother’s psychiatric treatment, exposing her to psychological harm due to increasing attachment before remanding the child, and risk to child due to potential unpredictable dangerous behavior driven by psychosis outweighed the benefits of visitation and breastfeeding in this challenging clinical case.